"Esther and the Genius" is the compelling story of the slow and tragic breakdown and dissolution of a prominent family. The life of Dr. Jordan Hartman, a successful but volatile professor, turns upside down with a call from his wife, Esther. Hartman is at the peak of his career; he has helped build the medical school into an internationally recognized research and treatment center. His attempt to save their teenage son Saul from a drug-selling goon ends in disaster. An avalanche of tragedy follows, involving the courts, the medical school, and ultimately destroying Hartman's family.